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AFMR - “Calcific Aortic Valve Disease: A Disease Process Comes of Age?”
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Title of symposium presentation: “Calcific Aortic Valve Disease: A Disease Process Comes of Age?”
Organizer Name: Kevin D. O’Brien, MD
Institution: University of Washington
Address: 1959 NE Pacific St., Seattle, WA 98195-6422
Abstract:
Calcific aortic stenosis, which includes aortic sclerosis and aortic stenosis, affects more than 25% of adults over age 65 years and is the second most common indication for cardiac surgery in the U.S. Over the past 10-15 years, calcific aortic valve disease has come to be recognized as an active process, and therefore, potentially amenable to pharmacological intervention. This symposium will review: 1) epidemiologic and genetic studies demonstrating associations of specific risk factors with increased prevalence or rate of progression of aortic valve disease, 2) histopathological studies, in humans and animal models, of chronic inflammation, lipoprotein deposition, renin-angiotensin system components in valve disease, including cell culture studies, 3) molecular mechanisms of valve calcification, and 4) the application of specific imaging techniques to monitor the effects of pharmacological therapies on valve disease progression in humans. Together, these talks will provide a current, comprehensive overview of molecular, cellular and clinical studies of this important cardiovascular condition.
Session Chairperson(s)*:
Kevin D. O’Brien, MD, University of Washington
Emile R. Mohler III, MD, University of Pennsylvania
| Presenters/Discussants*: |
| Kevin D. O’Brien, MD, University of WashingtonD |
| | “Epidemiology and Genetics of Calcific Aortic Valve Disease” |
| Emile R. Mohler III, MD, University of Pennsylvania |
| | “Human and Animal Models of Aortic Valve Disease” |
| Cecilia M. Giachelli, PhD, University of Washington |
| | “Molecular Mechanisms of Valve Calcification” |
| David M. Shavelle, MD, Harbor-UCLA Medical Center |
| | “Imaging Studies and Pharmacological Interventions in Aortic Valve Disease” |
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