2009 Southern Regional Meeting Abstracts

Purpose of Study: There is growing concern about late stent thrombosis, associated myocardial infarction and mortality with drug eluting stents (DES). The objective of the study was to determine the long term outcome of DES in real world setting and its comparison with bare metal stents (BMS).
Methods Used: Study cohort was formed by all patients who had percutaneous intervention (PCI) done during January 2003 to August 2004 at one institution. Data were obtained regarding cardiac risk factors, medications at discharge, angiographic details and outcomes including death, target lesion revascularization (TLR), stent thrombosis and major adverse cardiac event (MACE).
Summary of Results: A total of 461 interventions using stents were done in patients who were followed up for a mean duration of 50 ± 8 months. Cardiac risk factors and medications at discharge were similar in patients with DES and BMS. There were more smokers in the DES group. Vessels implanted with DES had a smaller mean diameter compared to BMS (2.9 mm vs. 3.2, P=0.001) and had longer lesion length (mean - 19 mm vs. 15 mm, P = 0.001). The long term outcomes were similar between the two groups (Table 1).
Conclusions: Over the follow up period, DES had similar rates of death, TLR, stent thrombosis, and MACE (compared with BMS) despite smaller lumen diameter and longer lesion length.

Table 1. Long term outcome in DES and BMS groups of patients

	BMS group (n= 290)	DES group (n=171 )	P value
Death	52 (18%)	22 (13%)	0.15
TLR (Target Lesion Revascularization)	58 (20%)	32 (19%)	0.73
Restenosis	53 (18%)	25 (15%)	0.53
Stent thrombosis	2 (0.7%)	4 (2.3%)	0.13
MACE (Major Adverse Cardiac Events)	110 (38%)	55 (32%)	0.21