Eastern Regional Meeting - 2008 Program & Abstracts
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AGE-ATTENUATION OF THE LIPOPROTEIN-ASSOCIATED RISK OF AORTIC VALVE CALCIFICATION (AVC) IN THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA)
D.S. Owens, R. Katz, E. Johnson, J.L. Probstfield, R. Kronmal, K.D. O'Brien, University of Washington, Seattle, WA; D.M. Shavelle, J. Takasu, M.J. Budoff, LA Biomedical Research Institute, Los Angeles, CA; J.R. Crouse, J.J. Carr, Wake Forest University, Winston-Salem, NC
Purpose of Study: Prior epidemiologic studies have shown LDL cholesterol to be an independent risk factor for AVC, but the effect of age on the lipoprotein-associated relative risk (RR) for AVC prevalence and severity has not been previously examined.
Methods Used: Using stepwise relative risk regression, the relationships of baseline fasting lipids to prevalence and severity of multislice CT-determined AVC were determined in 5,801 non-statin-using participants in MESA.
Summary of Results: In age-stratified, adjusted analyses, the LDL-associated RR (95% CI) for prevalent AVC was significantly higher for younger versus older participants [Figure 1; p-interaction = 0.04]. There was a similar interaction of age with Total cholesterol-associated RR for prevalent AVC (p interaction = 0.037). In contrast, Total/HDL cholesterol ratio RRs were similar across all age strata (Figure 1; p-interaction = 0.68). In multivariate analyses, no lipoprotein parameter was associated with AVC severity.
Conclusions: In this ethnically-diverse, preclinical cohort, LDL was a risk factor for AVC only in participants <65 years old, while the Total/HDL cholesterol ratio was associated with a modest increased risk for AVC across all ages. These findings have significant implications regarding dyslipidemia therapies in calcific aortic valve disease.
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